微生物发病机制杂志

A Agricultural Pathogen Becomes a Delivery Vehicle for Vaccines

Abstract

Abdjeleel Emeterio

The Vesicular Stomatitis Virus (VSV), a well-known livestock pathogen and prototypical non-segmented, negative-sense RNA virus, is a member of the Vesiculovirus genus and the family Rhabdoviridae. Even though the virus is to blame for economically significant epidemics of vesicular stomatitis in cattle, horses, and pigs, molecular biologists and virologists can still use VSV as a useful research tool. In fact, the development of a reverse genetics approach for the recovery of infectious VSV from cDNA altered this virus's functionality and opened the door for its application as a vaccine vector. Many other VSV-based vaccines have been developed, especially for high-consequence viruses. A highly effective VSVbased vaccination against the Ebola virus just got clinical licensure. This review aims to give a comprehensive but succinct understanding of VSV, documenting the virus's transformation into a viable medicinal countermeasure, with a focus on vaccinations, from a persistent agricultural scourge.