Gabriel McCoy and William Edenfield
We describe a case of newly diagnosed chronic myelomonocytic leukemia that presented with predominantly rheumatologic symptoms. In addition to the deletion of chromosome 12p, marrow cytogenetics also revealed a unique translocation, t(x:4). This finding was not a constitutive abnormality. We report this unusual chromosomal abnormality and hypothesize about the potential immunogenicity of the gene product and its relation to the patient’s rheumatologic complaints.
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