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??????????????????? 50% ?????? P53 ?????????????? P53 ???????????????????????????? P53 ?????? P53 ???????????????????????????????? P53 ???????? P53 ???????????????? P53 ??????????? R175?G245?R248?R249?R273 ? R282???? P53 ???????????????????????? p63?MRE11?Rad51-NSB ????p73 ? Sp-1???? P53 ????????????? SREBP?NF-Y?VDR?ETS2 ? NRF2???? P53 ??????? Zn+2??? microRNA ???? P53 ???????????PRIMA-1 ????????? P53 ?????????
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