冠心病杂志

AGXT2 和 DDAH-1 基因变异与埃及人的血清 ADMA 和 SDMA 水平以及冠状动脉疾病发病率高度相关

Abstract

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??????????????? (DDAH1) ???????????? 2 (AGXT2) ?????????????? (ADMA) ????????? (SDMA) ?????????ADMA ? SDMA ??????????????????? eNOS ??????? (NO) ?????????????????????????????? AGXT2 rs37369?AGXT2 rs16899974 ? DDAH1 rs997251 SNPs ???????????????? (CAD) ???????????????? ADMA ? SDMA ??????
??????? 150 ?????100 ? CAD ??? 50 ????????????? qPCR ???? ADMA ? SDMA ???? ELISA ???
??????????CAD ????? ADMA ? SDMA ????????p ??<0.0001??CAD ????????????? SNP ??????????????AGXT2 rs37369-T ?????CT+TT ????? AGXT2 rs16899974-A ?????CA+AA ??????????? SNP ?? CAD ?????? CC ???? 2.4 ?? 2.08 ??p=0.0050 ? 0.0192??DDAH1 rs997251 TC+CC ???? CAD ??? TT ???? 2.3 ??p=0.0063?????AGXT2 rs37369 TT ????AGXT2 rs16899974 AA ???? DDAH1 rs997251 CC ???????? ADMA ? SDMA ?????
??? AGXT2 rs37369-T?AGXT2 rs16899974-A ? DDAH1 rs997251-C ???????? CAD ????????