Yunfu Lv, XiaoYu Han, Xiaoguang Gong, Wenbiao Gu, Chao He, Hongfei Wu, YeJuan Li and Jie Den
Objectives: To explore the constituent ratio of peripheral blood cells changes in patients with splenomegaly due to posthepatitic cirrhotic portal hypertension and its postoperative prognosis, and to grade the peripheral cytopenias.
Methods: Data of 366 cases of splenomegaly due to posthepatitic cirrhotic portal hypertension were collected and analyzed.
Results: Thirty-six patients (9.8%) had a normal blood cell count and 330 patients had peripheral cytopenias, in which mono-lineage cytopenias accounted for 30% (99/330), bi-lineage cytopenias accounted for 35.8% (118/330) and tri-lineage cytopenias accounted for 34.2% (113/330). There were significant statistical differences (P<0.05) in the postoperative prognostic comparison between mono-lineage cytopenias and multi-linage cytopenias. In the 330 cases of cytopenias, the postoperative prognosis demonstrated significant differences between thrombocytopenia, leukopenia and erythropenia (P<0.05). For the most part, according to the severity of thrombocytopenia, cytopenia was graded as mild, medium and severe, and scored as <2 points, 2-3 points and >3 points, respectively. The prognosis revealed significant differences between the three grades (P<0.05).
Conclusions: Peripheral cytopenias can influence postoperative prognosis. Thrombocytopenia is a major factor influencing postoperative prognosis and grading is of great significance in analyzing the condition of inpatients and guiding their treatment.
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