临床病例报告杂志

Angioedema-Induced By Angiotensin Converting Enzyme Inhibitors

Abstract

Blum Arnon

Angioedema is a known allergic reaction to many medications. Angiotensin Converting Enzyme Inhibitors (ACE-I) have been reported to cause such an adverse event, however, the mechanism of action is not clear enough. ACE-I induced angioedema is often misdiagnosed, although it could develop to a life-threatening situation. It is believed that it is caused by bradykinin induced activation of vascular bradykinin B2 receptors. Studies have reported an incidence of angioedema of 1 in 1000 during the first week of use, and 1 to 42,000 subsequently. Life threatening airway obstruction requiring intubation has been reported in up to 22% of angioedema cases caused by ACE inhibitors, with an overall mortality rate of 11%.