药物化学

Anti-diabetes and Anti-inflammatory Activities of Phenolic Glycosides from Liparis odorata

Abstract

Hongdong Liu, Bin Li, Piao Jiang, Youquan Zhong, Dongming Zhang, Hua Liu, Pingnan Wan, Xuewen Lai, Bo Liu and Jie Chen

Five new phenolic glycosides, liparisglycoside K-O (1-5) and one known compound, 4-allyl-2,6-dimethoxyphenol glucoside (6) were isolated from the whole plant of Liparis odorata. Compound 6 was isolated and identified from this genus for the first time. The structures of all compounds were elucidated through extensive spectroscopic methods including UV, IR, MS, 1D- and 2D-NMR. All compounds from Liparis odorata were evaluated for their ability to inhibit LPS-induced NO production on the BV2 microglial cell line in vitro, as well as their inhibitory effects on PTP1B and α-glucosidase enzyme assays.