神经系统疾病

Assessment of Genetic Mutations in Genes DSM-IV, DRD4, SERT, HTR1B, SNAP25, GRIN2A, ADRA2A, TPH2 and BDNF Induced Attention Deficit Disorder and Hyperactivity in Children

Abstract

Shahin Asadi, Mahsa Jamali, Zahra Gholizadeh, Mina Niknia and Maryam Safi

In this study we have analyzed 1200 people, 580 ADHD and 620 control groups. The genes DSM-IV, DRD4, SERT, HTR1B, SNAP25, GRIN2A, ADRA2A, TPH2 and BDNF analyzed in terms of genetic mutations made. In this study, people who have genetic mutations were targeted, with nervous disorders, ADHD. In fact, of all people with ADHD, 360 children had a genetic mutation in the genes DSM-IV, DRD4, SERT, and HTR1B. And 100 children had a genetic mutations in SNAP25, GRIN2A genes were a genetic mutations in the genes ADRA2A, TPH2 and BDNF and 70 children, respectively. Any genetic mutations in the target genes control group, did not show.

Hypothesis and objectives: In this study, we further understand the genes involved in ADHD children with the genetic mutations discussed. The aim of this study was to evaluate genetic and epigenetic closer to induce hyperactivity disorder in children.