法医学杂志

免疫球蛋白受体、抗原 C 与慢性肝排斥风险升高之间的关联

Abstract

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?????????????????????????????????????????????????? I ???????? (HLA-I) ???????????? (NK) ?????????????????????????????????? CR ?????????????????????????????????? (PCR-SSO) ????? 513 ???????? KIR ? HLA ??????????????? KIR???????? C (HLA-C) ????KIR ????? KIR/HLA ????????? CR (n=35) ?????? (NCR=478) ???????????????? NCR ???????????? KIR (aKIR) ?? (rKIR2DS2+ ? rKIR2DS3+) ??? CR ?? (p=0.013 ? p=0.038)????????? KIR (iKIR) ?????? rKIR2DL2+???????? KIR ?????CR ????? (9.1% ? 3.7%?p=0.020)?KIR2DL3 ???? CR ????? (13.1% ? 5.2%?p=0.008)?? NCR ????????? HLA-I ?? (MM) ?????? CR??? (d) HLA-C2 ?? (dC2−) ?????????CR ???? (13.1% ? 5.6%?p=0.018)?? rKIR2DL3+/dC1− (p=0.015)?rKIR2DS4/dC1− (p=0.014) ? rKIR2DL3+/rKIR2DS4+/dC1− (p=0.006) ???????CR ????????? 5-10 ??rKIR2DS1+rKIR2DS4+/dC1− ????????????????????????? rKIR/dHLA-C ??? aKIR ??????? CR ???????? KIR2DS1+/C1 ??? KIR2DS4+/C1 ???????????????