遗传学与基因组杂志

Association between Vitamin D Receptor Gene Polymorphism, Secondary Hyperparathyroidism and Ultrasound Densitometry Parameters in Postmenopausal Women

Abstract

Povoroznyuk V, Balatska N, Grygorieva N, Mouhaidly O

Background: Many studies have confirmed that the vitamin D receptor (VDR) polymorphism might be associated with the risk of systemic osteoporosis and its complications. The aim of the study was to find out the association between VDR gene polymorphism and secondary hyperparathyroidism and bone tissue status in postmenopausal women.
Patients and methods: 178 postmenopausal women (mean age 57.0 ± 1.2 years) were examined from the western (36.5%), eastern (24.7%) and northern (38.8%) regions of Ukraine. Vitamin D receptor polymorphisms were defined using the RLFP reaction. After the analysis, samples were classified as BB, Bb or Bb. The serum content of 25(OH) vitamin D (25(OH)D) and intact parathyroid hormone (iPTH) were defined by electrochemiluminescence method. All examined patients underwent ultrasonic calcaneal densitometry.
Results: Women with a genotype Bb had lower percentage of osteoporosis and low-energy fractures. Women, who live in the east of Ukraine, more often are carriers of genotype BB (20.5%), have a higher risk of fractures, vitamin D deficiency and secondary hyperparathyroidism. Patients who carry bb genotype have a higher risk of osteoporosis and secondary hyperparathyroidism.
Conclusion: Genetic variations in VDR are significantly associated with vitamin D deficiency, secondary hyperparathyroidism and osteoporosis among Ukrainian postmenopausal women. Further studies are required to confirm the role of the VDR polymorphisms in development of postmenopausal in older age women.