..

Biflorin, A Naphthoquinone, Inhibitsegfr in Breast Cancer Cells

Abstract

Raquel C Montenegro, Rommel R Burbano, Milton N da Silva, Telma G Lemos and Marne C Vasconcellos

The ErbBreceptor family has been used as therapeutic target for treatment of several types of cancer. Biflorin is a natural ο-naphthoquinone with anticancer properties. Herein, we described the effect of biflorin on cell growth and EGFR expression in SK-Br3 human breast cancer cell line with high EGFR expression. Biflorin significantly inhibited breast cancer cell growth, in a dose- and time-dependent manner as determined by the Alamar Blue assay. Noncitotoxicity were observed in normal MCF-10A breast cell line. Furthermore, biflorin inhibited EGFR expression in a dose-dependent manner. Biflorin can be used as a drug lead for new molecules against EGFR.

免责声明: 此摘要通过人工智能工具翻译,尚未经过审核或验证

分享此文章

索引于

相关链接

arrow_upward arrow_upward