Adeoye Oyetunji Oyewopo, Adetobi Tosin Emmanuel *, Alakanse Suleimon Oluwaseun, Omole Tosin Tabel
Infertility has been one of the most common issue in the medical field, male infertility is more common and can be expressed in several forms, moreover a decrease in male reproductive hormones has been proven to affects spermatogenesis and due to this reason, pharmacognosy has been explored by researchers to provide alternatives for this problem. Symphonia globulifera, a plant widely distributed across the neotropic region and equatorial Africa has been used in traditional medicine due to its potency caused by the presence of potent metabolites.
Objectives: This study is carried out to evaluate the bioactive effect of globulixanthone B on spermatogenesis and male infertility
Method: This study was carried out using molecular docking to analyze the binding energy of the phytocompounds in symphonia globulifera on CYP11A, 3B-HSD, LHR and FSH-R which were furtherly visualized to calculate the chemical properties between the ligands and the receptors then the lead compound was register for druglikeness screening.
Results: This study has shown that Globulixanthone B is a lead compound with a significant binding energy with good binding affinity due to it hydrophobic interactions with the receptors. It has fufilled the five rules of druglikeness properties.
Conclusion: This present work shows that Globulixanthone B is not only an highly efficacious compound but also a therapeutic alternative for boosting spermatogenesis and reducing
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