癌症科学与治疗

蓝藻毒素的生物活性及对肝细胞癌的细胞毒作用

Abstract

Ahmed WA?El-Semary NA?Abd El-Hameed OM?El Tawill G ? Ibrahim DM

????????????????????????????????????????????????????????????????????????????? 23S rDNA ????????????????????????????? Plectonema ?????????????????????????? (HepG2) ???????? (Cyanothece sp.) ? (Plectonema terebrans) ?????????????????????????????IC50 ???? 13.3% ? 8.3%???????????????? caspase3 ???????????6.6%?????Cyanothece sp.???Plectonema terebrans?????????????? 66.7% ? 57.4%?????????????? Cyanothece sp ?????? G0/G1 ? G2/M ????????? 52.8% ? 0.33%??2n ???????46.4%???? Plectonema terebrans ????????????G0/G1 ??? 63.3%?G2/M ??? 0.3%?2n ??? 35.6%??G0/G1 ? G2/M ???????????? 7.38% ? 0.13%??2n ????????91.8%???????????????? Caspase-3 ???????? 13.3% ????????? 0.397 ± SD 0.02???????????? Caspase-3 ???????? 4% ????????? 0.402 ± SD 0.002????????? (0.157 ± SD 0.05 nM/mL) ???? (p<0.05)??????????????????????????