组织科学与工程学报

Bone Regenerative Medicine and Bone Grafting

Abstract

Somayeh Monazzah Harsini and Azizollah Khodakaram Tafti

Bone tissues can repair and regenerate itself in many clinical cases, bone fractures repair without scar formation. Nevertheless, in large bone defects and pathological fractures, bone healing fail to heal. Bone grafting is defined as implantation of material which promotes fracture healing, through osteoconduction osteogenesis and osteoinduction. Ideal bone grafting depends on several factors such as defect size, ethical issues, biomechanical characteristics, tissue viability, shape and volume, associated complications, cost, graft size, graft handling, and biological characteristics. The materials that are used as bone graft can be divided into separate major categories, such as autografts, allografts, and xenografts. Synthetic substitutes and tissue-engineered biomaterials are other options. Each of these instances has some advantages and disadvantages. Between the all strategies for improving fracture healing and enhance the outcome of unification of the grafts, tissue engineering is a suitable option. A desirable tissue-engineered bone must have properties similar to those of autografts without their limitations. None of the used bone grafts has all the ideal properties including low donor morbidity, long shelf life, efficient cost, biological safety, no size restriction, and osteoconductive, osteoinductive, osteogenic, and angiogenic properties; but Tissue engineering tries to supply most of these features. In addition it is able to induce healing and reconstruction of bone defects. Combining the basis of orthopedic surgery with knowledge from different sciences like materials science, biology, chemistry, physics, and engineering can overcome the limitations of current therapies. Combining the basis of orthopedic surgery with knowledge from different sciences like materials science, biology, chemistry, physics, and engineering can overcome the limitations of current therapies.