化学科学杂志

Catalytic Innovations in Unlocking the Potential of Transition-metal-catalyzed C-H Activation for Precision Functionalization

Abstract

Khadim Dioukhan

In the world of organic synthesis, the ability to selectively functionalize Carbon-Hydrogen (C-H) bonds has long been a holy grail. The direct transformation of C-H bonds into valuable chemical functionalities could revolutionize the way we build complex molecules. Transition-metalcatalyzed C-H activation has emerged as a powerful tool to achieve this goal. Recent advances in this field have opened up exciting opportunities for precision functionalization, transforming the way chemists approach synthesis and offering new pathways to challenging molecules. Transitionmetal- catalyzed C-H activation is a groundbreaking technique in the field of organic chemistry. It involves the use of transition metal catalysts to facilitate the direct transformation of Carbon-Hydrogen (C-H) bonds into more valuable chemical functionalities without the need for prior functional group manipulation. This approach has revolutionized the way chemists synthesize complex molecules and has found wide-ranging applications in the pharmaceutical, materials science and chemical industries.