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Circulatory Histidine levels for the assessment of disease activity in Takayasu arteritis: A targeted NMR based serum metabolomics study

Abstract

Umesh Kumar

Quantitative assessment of disease activity
is important for effective disease management in
Takayasu arteritis (TA) which is an immune-mediated
inflammatory disease. The dominance of oxidative stress
is the hallmark of active inflammation. Both clinical and
preclinical data suggest that histidine has its strong antioxidative
and anti-inflammatory effects [1,2]. Based on
this, we hypothesized that the circulatory Histidine can
serve as an indicant of active inflammation and so for
monitoring disease activity in TA.