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临床神经病学和神经外科杂志

Coffee Consumption Provides Therapeutic Benefits against AD through Increasing Plasma GCSF Levels and Improving Cognitive Performance

Abstract

Umer Nawaz Khan and Chuanhai Cao

Alzheimer's disease (AD) a progressive neurodegenerative disease that destroys memory and other important mental functions. More than 5 million Americans are living with AD. This number is expected to drastically increase as the baby boomer population transitions into the late-adulthood age group. Currently, the treatment for AD includes FDA drugs that focus on treating the symptoms. These types of drugs lose their efficacy as the disease progresses. Therefore, preventive measures are very critical in decreasing the incidence rate of AD. Many epidemiological studies have been conducted on the treatment of Alzheimer's that suggest enhanced coffee/caffeine intake during aging reduces the risk of AD. As one of most popular beverages in the World, many experimental studies have been done to test the effects of coffee consumption on AD. This paper will aim to review the important discoveries that have been made recently and present the possible mechanisms behind the neuroprotective effects.

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