Pierre Kolber and Rejko Krüger
Parkinson’s disease (PD) is increasingly recognized as a heterogeneous disorder combining equally diverse motor and non-motor symptoms, with a complex interplay and different individual presentations, especially in the advanced stages of the disease. Current classifications and related stage-adapted therapeutic recommendations still lack of precision, as traditional concepts of advanced PD (advPD) are mainly based on milestones of motor disabilities. In this short review, we present the concepts delineated by Krüger and colleagues published in the ‘Journal of Neural Transmission’ on current classifications for advPD and novel directions for future clinical trials, a precision medicine approach by empowerment of patients and their involvement in therapeutic decisions.
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