癌症科学与治疗

卵巢癌及其相关子宫内膜异位症中差异表达 miRNA 及其下游 mRNA 的比较分析

Abstract

Richard Li Cheng Wu?Shadan Ali?Sudeshna Bandyopadhyay?Baraa Alosh?Kinda Hayek?MHD Fayez Daaboul?Ira Winer?Fazlul H Sarkar ? Rouba Ali-Fehmi

????????????????? (OC) ???????????????????????????????????microRNA (miRNA) ?????? RNA??????????????????????????????????????????????? 19 ???????????????????? miRNA ????????????????? miRNA ??????

???????????? 19 ???????????????????????????????? RNA??????????????????????????? miRNA ???????????? PCR (qRT-PCR) ???????????? miRNA ??????Ingenuity ????????? mRNA???? qRT-PCR ??????

??? miRNA ???? OC ???? 1156 ? miRNA ?????????? miRNA ????? qRT-PCR ?????????????????OC ??? miR-1?miR-133a ? miR-451 ???????p<0.0001???????? OC ??? miR-141?miR-200a?miR-200c ? miR-3613 ???????p<0.05???????? miRNA ??? mRNA ?????????????OC ??? PTEN ?????????p<0.05??? NF-κB ????????

??? OC???????????????miRNA?mRNA?????????????????miRNA?????????????OC??????????????