分子生物标志物与诊断杂志

Current Trends in Prophylactic Mastectomies for Unaffected BRCA Mutation Carriers

Abstract

Elizabeth Ulrich BS, Dan Yoho, Kenneth Moquin

Breast cancer remains the most common cancer diagnosis in women, as it represents 14.6% of new cancer diagnoses in the United States and accounts for 6.8% of cancer deaths. Growing research into breast cancer etiology has shed new light on genetic risk factors. It is now estimated that 5% to 10% of all breast cancers have a hereditary link. This is especially true in younger patients, in whom 25% to 40% of cases have a coexisting genetic risk.