神经系统疾病

Editorial on Neuroplasticity and Antipsychotics in Treatment of Schizophrenia

Abstract

Fandino-Franky J

This paper is a deep and fortunate revision of medical literature about causes of schizophrenia and some future treatment of this controversial disease. The author carries the lector to the concept of neuroplasticity, the roll of Dopamine and GABA, as well as the excitatory glutamate over the dorsolateral prefrontal cortex of the brain, where he sustains (with important literature) reside the crucial anatomo-phisiological part of the brain for schizophrenia. Very interesting aspects are explained, based on studies performed since 2000 by Elvevag [1], over presented brain atrophy in schizophrenia due to neurotoxicity and neurodegeneration “that involved loss of neurons in the gray matter with marked reduction in the number and size of dendritic extensions”. The author tries to explain after Wakade´s [2] investigations that haloperidol produces neurotoxicity and cell apoptosis opposite to second generation antipsychotics that stimulate neurogenesis.