药物化学

Effect of Maxima Suppressor and Supporting Electrolyte on Polarographic Wave of Dimethyl Sulfoxide and its Determination

Abstract

Swaroopa Rani N Gupta

The oxidation of the biologically very important dimethyl sulfoxide system has been the subject of investigations. In present study Dimethyl sulfoxide (DMSO) can be oxidized to dimethyl sulfone by anodic electrolysis at a rotating platinum electrode. The polarographic method has been used to study qualitatively the effect of maxima suppressor gelatin, fuchsin, methyl red, thymol blue and supporting electrolyte HCl, CH3COOH on oxidation wave of DMSO. Polarographic oxidation of DMSO in 0.1 M HCl, 0.1 M CH3COOH solution using optimum concentration of fuchsin, methyl red, thymol blue as surface active substances is followed to determine the DMSO present in synthetic sample by calibration method. Wave analysis indicate the irreversible nature of the oxidation process which involves oxidation of dimethyl sulfoxide to dimethyl sulfone thereby increasing the oxidation state of sulphur from +2 to +4 state.