神经系统疾病

Fatal Ischemic Stroke in a Patient with Mild Covid-19 Infection

Abstract

N. Mouloudi, C. Moussavou, Y. Benmoh and A. Bourazza

Coronavirus disease 2019 (COVID-19) is a worldwide pandemic. It is currently established that patients with COVID-19 have a high risk of thromboembolic complications such as acute ischemic stroke which emerge as a serious complication of infection by the severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2). In this sense, we present the case of a 68 year old male with a history of mitral valve replacement that developed a devastating acute ischemic stroke in multiple vascular territories in the setting of mild COVID-19 infection despite adherence to therapeutic anticoagulation. It is likely that multiple mechanisms are involved in stroke related to COVID-19. Although, vascular inflammation and coagulopathy are emerging as features defining pathology underlying COVID-19. Given the failure of anticoagulants in the prevention of ischemic strokes in some cases, despite an optimized anticoagulation strategy, more research is required to explore new methods of anti-thrombotic and anti-inflammatory therapy for stroke prevention in patients diagnosed with COVID-19.