???·???? (Ilya Tsimafeyeu)???·???? (Lev Demidov)????·????? (Galina Kharkevich)?????·??? (Natalia Petenko)????·???? (Maria Volkova) ??????·????? (Vsevolod Matveev)
???????????????????????????????? (GM-CSF)???? α (IFN) ?????? 2 (IL-2) ???????? (RCC) ?????????????????????? (T3b-4 ? N1-2) ???? (M1) RCC???????????????????? 6 ????????GM-CSF?1 mcg/kg??? 3 ?????????????IFN?10 MIU??? 3 ???????????IL-2?1 MIU??? 3 ??????????????????????????????? (DFS)?????????????? (OS)?????????? Dixon ? Simon ????????? 35 ????35 ??????????28 ??/7 ??????? = 46 ???? 21-71 ??ECOG 0-1?14 ??40%???? III ??21 ??60%???? IV ????????????????????????????? DFS ? 14.1 ???95% CI?3-20.2 ??????????? 5.1 ?????? 65.7%?OS ? 40%??? OS ? 53.0 ???95% CI?40.6-65.4 ????????? N2/M1 ?? 5 ? DFS ? OS ???????????????????????????????????? RCC ????????????? GM-CSF?IFN ? IL-2 ???? DFS?
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