癌症科学与治疗

宿主 H67D 基因型影响小鼠黑色素瘤的肿瘤生长

Abstract

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?????????????HFE????????????????????? HFE ????????????????

??? 18 ???? C57BL/6 ????? H67D/H67D ? WT/WT HFE ???????? 4x106 ? B16F10 ????????????2 ???????????????????????? IACUC ????04-166???? RT-PCR ??????????????????????? B16F10 ???????????????????????????????????????????????????????????? ELISA ??????????H67D ??????????t ???P = 0.02???????? qRT-PCR ?????H67D ????????????????????? H67D ?????????????????????? 1 (MCP1)???????????? (p = 0.02)????? H67D ??????????????? B16F10 ???????? WT ??????????????????? (p < 0.01 MTT?p < 0.01 BrdU)???????????H67D ?????? Ferroportin ?? (p = 0.03)?????? H67D ??????????????????? WT ????????????? HFE ??????????????????????????