Jacqueline A Fiuza and Soraya T Gaze
Among the clinical forms of leishmaniasis, visceral leishmaniasis is the most debilitating clinical form because it compromises mainly liver and spleen in the host. The immune response against the parasite and immune factors relating to protection or susceptibility are not well established. Experimental models and natural infection in dogs also have different patterns to human disease. In the scientific community, many groups are developing different strategies to find an effective vaccine that could be used in dogs, and/or human in the future, with success. The vaccine to leishmaniasis, together with other sanitary strategies, could decrease the infection rates in endemic countries. Here, it is presented a review of the last studies focusing in a vaccine against visceral leishmaniasis.
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