法医学杂志

免疫球蛋白受体和抗原 C 增加慢性肝排斥的风险

Abstract

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?????? (CR) ????????????????????????????????????/I ???????? (KIR/HLA-I) ????????????? (NK) ????????????????????????? CR ???????????????????????? (PCR-SSO) ???? 513 ?????? KIR ? HLA ??????????????? CR (n=35) ??????? (NCR=478) ?? KIR???????? C (HLA-C) ????KIR ????? KIR/HLA ????????????? (rKIR2DS2+ ? rKIR2DS3+) ????? KIR (aKIR) ????? CR ? NCR ? (p=0.013 ? p=0.038)??? rKIR2DL2+ ????? KIR (iKIR) ??????? CR ????? (9.1% ? 3.7%?p=0.020)?KIR2DL3 ????? CR (13.1% ? 5.2%?p=0.008)?? NCR ?????? HLA-I ?? (MM) ???? CR??? (d) HLA-C2 ?? (dC2−) ??????????????? CR (13.1% ? 5.6%?p=0.018)?? rKIR2DL3+/dC1−(p=0.015)?rKIR2DS4/dC1−(p=0.014) ? rKIR2DL3+/rKIR2DS4+/dC1−(p=0.006) ???? CR ??????

??? 5-10 ??rKIR2DS1+rKIR2DS4+/dC1− ??????????????????? rKIR/dHLA-C ??? aKIR ????? CR ? KIR2DS1+/C1-????????? KIR2DS4+/C1-??????????????