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MDM2 SNP309T>G 多态性的影响:印度患者罹患非小细胞肺癌的风险增加且预后不良

Abstract

Jamsheed Javid?Rashid Mir?M Masroor?Shazia Farooq?Imtiyaz Ahamad?Prasant Yadav?Maryam Zubari?PC Ray?Ajaz Ah Bhat?PK Julka?Anant Mohan?Maqbool Lone?MA Banday ? Alpana Saxena

??? MDM2 ? TP53 ???????????????????????????MDM2 ?????????????????????????????????????????????????????????? MDM2 ????????????????????? 136 ?????? NSCLC ?????? 136 ????????????????????????????? ??ARMS-PCR ? ASO-PCR ??? MDM2 ??????????c.–51309G4T?rs2279744:g.G4T??? NSCLC ???????????? MDM2-2580TT ?????????? MDM2-309G ???????????? NSCLC ???????[GG ???? OR 3.88 (1.82-8.27) RR 1.94 (1.27-2.96) RD 32.6 (15.7-49.6) p 0.0004?GT ???? OR 2.60 (1.49-4.57) RR 1.52 (1.20-1.93) RD 23.16 (10.3-36.0) p 0.0009]?GG ???? NSCLC ?????????????????? NSCLC ????? (p 0.01) ????? (p 0.002) ?????????????????? MDM2 ??????????????? NSCLC ???????G ????? T ???????????????????
 

 

 

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