癌症科学与治疗

Survivin 反应性条件复制腺病毒联合顺铂对肺癌的抗肿瘤作用增强

Abstract

????Ali Sakhawat???????????

????????????DDP??????????????????????????????????????????????????????????????Survivin ??????????????????????????? Survivin ???????????????????????????????????????????????????????????????? NCI-H292 ? NCI-H66??????????? E1B ????? Survivin ??????????? (CRAd)???? MTS ?????????????????????DDP ? CRAd??????????RT-PCR????????????????????CAR????????MTS??????DDP?CRAd??????64μg/ml?800 MOI?????????????70??60?????????DDP?4μg/ml??CRAd?100 MOI?????????DDP + CRAd????????????????????????????????????RT-PCR???????????CAR????????????????????Survivin??????CRAd?DDP???????????????????????????????????????????????Survivin???????CRAd???????????