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印度首项研究表明,启动子高甲基化导致 RIZ1 基因失活与印度慢性粒细胞白血病患者的病情进展和对伊马替尼的耐药性有关

Abstract

Imtiyaz Ahmad?Rashid Mir?Mariyam Zuberi?Jamsheed Javid?Prasant Yadav?Shazia Farooq?M. Masroor?Sameer Guru?Sheikh Shahnawaz?PC Ray?Ishfaq Ahmed Sheikh?Tanvir Khatlani?Ajaz Ah Bhat?Naresh Gupta?Sunita Jetly?Niyaz Ahmad?????·????

???DNA???????????? (CML) ?????????
????????????RIZ1 ?????????? CML ???????? RIZ1 ?????????????RIZ1 ??? PR ???????????????? H3 ??? 9?????????????????? CML ??????????RIZ1 ?????????? 1 ???????????????????????RIZ1 ??? CML ?????????????????????????????????? CML ??????????????? MSP ????? 100 ????????? (CML) ??? 50 ????? RIZ1 ???????????
??????100?CML???RIZ1??????9???????
?????6???????2???????1???????????????????RIZ1????????????????42% vs 2%?????????16.77% vs 1.92%??RIZ1???????????????????????????????????CML????RIZ1?????????????????????RIZ1????????????????p<0.003??RIZ1??????CML?????????????bcr/abl????????????
??????????RIZ1 ?????????? CML ????????????
????? RIZ1 ?????? CML ??????????????????

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