Hanan Rida1*, H. Zaine1, H. Jouhadi1, D. Bentaleb2, M. Sabiri2 and F. Essodegui2
Leptomeningeal carcinomatosis is an exceedingly rare complication of prostate cancer. However, its incidence may increase as prostate cancer patients survive longer with new therapies even after castration resistance. The clinical presentation is varied and nonspecific. The diagnosis of leptomeningeal metastatic disease is made either by identifying malignant cells in cerebrospinal fluid or by gadolinium-enhanced MRI. Several treatments, including radiation therapy, intrathecal chemotherapy, steroids, debulking surgery, and best supportive care have been suggested. Although, the prognosis is extremely poor not exceeding weeks. We report a case of leptomeningeal carcinomatosis in a 64-year-old patient with metastatic castration-resistant prostate cancer with a review of the literature.
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