微生物发病机制杂志

Microbial Pathogenesis: The Impact of Biofilm Formation on Infection

Abstract

Jennifer Bomberger

Microbial pathogenesis is a complex process that involves the interaction between microorganisms and the host, leading to infection and disease. One crucial aspect of microbial pathogenesis is the formation of biofilms, which are structured communities of microorganisms encased in a self-produced extracellular matrix. Biofilm formation significantly impacts the progression and severity of infections by providing microorganisms with enhanced resistance to host immune defenses and antimicrobial treatments. In this paper, we review the current understanding of microbial pathogenesis with a specific focus on the impact of biofilm formation on infection. We discuss the mechanisms underlying biofilm formation, the advantages conferred by biofilms to pathogens and the implications for clinical management. By elucidating the role of biofilms in microbial pathogenesis, we can develop better strategies for preventing and treating biofilm-associated infections.