微生物发病机制杂志

Microbiota Changes in Guinea Pigs with Cough Variant Asthma: Insights from Lung, Ileum and Colon

Abstract

Lori Stone

Cough Variant Asthma (CVA) represents a distinct phenotype of asthma characterized by chronic cough as the sole or predominant symptom. While the pathophysiology of CVA remains incompletely understood, emerging evidence suggests a potential role of the gut-lung axis and alterations in the gut microbiota. In this study, we investigated microbiota changes in guinea pigs with experimentally induced CVA, focusing on the lung, ileum, and colon. Through 16S rRNA gene sequencing and metagenomic analysis, we identified significant dysbiosis in all three compartments, with alterations in microbial composition and diversity. Our findings underscore the complex interplay between the respiratory and gastrointestinal systems in CVA and provide insights into potential therapeutic targets for modulating the gut microbiota to ameliorate asthma symptoms.