制剂科学与生物利用度杂志

Navigating Drug Development: Formulation Engineering and Bioavailability Analysis

Abstract

Tony Zhou

Drug development is a complex and meticulous process that requires numerous steps to bring a new therapeutic agent from conception to the market. Among the pivotal stages is formulation engineering and bioavailability analysis, where the drug is crafted into a viable product with optimal efficacy and safety profiles. This article delves into the crucial steps involved in these processes and highlights their significance in the pharmaceutical industry. Formulation engineering involves the art and science of designing a drug product that ensures stability, efficacy and patient compliance. It begins with selecting appropriate drug candidates and excipients, followed by optimizing the formulation to achieve the desired therapeutic outcome. Several factors influence formulation design, including the physicochemical properties of the drug, route of administration, and intended dosage form.