麻醉学和疼痛研究杂志

Oral Medication Absorption and Disposition in Patients with Critical Illnesses of the Heart

Abstract

Neuer Yuloo

Patients with critical heart illnesses often present a unique set of challenges in the administration and management of oral medications. The absorption and disposition of oral medications can be significantly altered by the pathophysiological changes associated with heart diseases, the use of concomitant medications, and the need for rapid and effective therapy. This article explores the complexities of oral medication absorption and disposition in patients with critical heart conditions, shedding light on the factors that influence drug pharmacokinetics and the strategies to optimize drug therapy. Heart failure is a common critical heart condition that affects millions of individuals worldwide. In heart failure, the heart's ability to pump blood efficiently is compromised, leading to a decrease in systemic perfusion and oxygen delivery to vital organs. This condition often requires multiple medications to manage symptoms, improve cardiac function, and reduce mortality.