Jochanan E. Naschitz
The present paper explores the effects of the psychopharmacological agent - fluoxetine - on mnestic processes, using a model of passive avoidance on male Wistar rats with different nervous system phenotypes and different activity ratios of the monoaminergic systems of the brains. In the re-test session under administration of fluoxetine, the seizure-tolerant rats compared to the seizure-sensitive rats were characterized by a more pronounced fear response to the "unsafe" compartment and enhanced anxiety facilitating the retention of memory trace. The individual sensitivity of the animals to the action of fluoxetine and the direction of its effects on mnestic processes are supposed to be determined by different primary activity ratios of the monoaminergic systems of the brain.
分享此文章
English 
Spanish 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 