神经系统疾病

Parkinson's Disease: A Concise Overview of Etiology, Epidemiology, Diagnosis, Comorbidity and Management

Abstract

Getinet Ayano

Parkinson's disease is a progressive neurodegenerative disorder that is associated with the loss of dopaminergic neurons in the substantia nigra pars compacta (SNc). It is a degenerative disorder of the central nervous system that belongs to a group of conditions called movement disorders. It is both chronic, meaning it persists over a long period of time, and progressive, meaning its symptoms grow worse over time. As nerve cells (neurons) in parts of the brain become impaired or die, people may begin to notice problems with movement, tremor, stiffness in the limbs or the trunk of the body, or impaired balance. As these symptoms become more pronounced, people may have difficulty walking, talking, or completing other simple tasks .