癌症科学与治疗

术后放疗联合重组腺病毒人P53基因治疗口腔癌Ⅱ期临床研究

Abstract

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???????????p53?rAd-p53????????????????????????????????????215????????TCa????268?????????GCa????????????EG??????CG??EG????????????????1×1012?????VP?rAd-p53?EG?CG?????3??????60 Gy???????????????3????????483?????107??EG 57??CG 50?????3????? EG??2??2/27?TCa?2??2/30?GCa?????????CG??8??8/24?TCa?8??8/26?GCa?????????CG?TCa????33.3%??GCa????30.8%????EG?TCa????7.4%??GCa????6.7%????????????EG??????7.0%???CG??32%????????????EG??3?????OS??100%????????PFS??93.0%???PFS???29???CG?3?OS??PFS????94.0%?68.0%?????????????rAd-p53??????????????????????rAd-p53??????????????TCa?GCa??????????OS?PFS?