癌症科学与治疗

免疫组织化学测定的早期淋巴结阴性 Luminal-B 乳腺癌中的孕酮受体表达水平：预测意义、结果和与 Oncotype-DX 复发评分的一致性

Abstract

Hala Ahmed Zaghloul1,2*?Lulwah Abduljabbar2?Karim Abdel Halim3 ? Miral Mashhour4

??????????PR???????????????????? B ?????Ki67 ? ≥ 14% ? <30% ???Oncotype-DX ?????RS??????????????

?????? PR ??? Oncotype-Dx RS ????????????????????????????????? (RFS)???????????????? (HR) ???????????????????? (RT-PCR)??????

???????? 250 ????????????? Luminal-B1?Ki67 ≥ 14%-<20%?? Luminal-B2?Ki67 ≥20%-<30%????????? Oncotype-DX RS?? Luminal-B1 ? B2 ??PR ≤ 20% ???????P=0.013?0.012?? Oncotype-DX RS ???P=0.003?0.001???????????PR ≤ 20% ????? RS ???????????????P<0.0001?0.002?? Cox ???????Oncotype-Dx RS ??? PR ≤ 20% ? RFS ?????????????? 1.84?95% ???? [CI]?3.67-8.14?? 2.53?95% CI?2.62-6.12?????????? RT-PCR ??? ER ? PR ? 98.2% ? 86.7% ???????

???????????? B ??????Ki67 ?? ≥14% ? <30% ???PR ≤ 20% ??? RS ??????????????? RS ? PR ≤ 20% ????????????????????????? RT-PCR ??? HR ???????????????ER ? PR ???? 98.2% ? 86.7%?