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Protein Quality Control of NKCC2: Implications for Bartter Syndrome and Blood Pressure Regulation

Abstract

Tungurasekula Kim*

Bartter Syndrome is a genetic disorder characterized by a set of renal tubulopathies that result in electrolyte imbalances, metabolic alkalosis and impaired blood pressure regulation. A key protein involved in this condition is the Na-K-2Cl Cotransporter 2 (NKCC2), which plays a crucial role in renal salt reabsorption. Proper functioning and regulation of NKCC2 are essential for maintaining electrolyte balance and normal blood pressure. This abstract reviews the role of protein quality control mechanisms in the regulation of NKCC2 and their implications for Bartter Syndrome and blood pressure homeostasis. We explore how mutations or dysfunctions in these quality control processes can lead to altered NKCC2 function, contributing to the clinical manifestations of Bartter Syndrome. By integrating recent research findings, this review aims to elucidate the complex interplay between protein quality control and NKCC2 activity and how these interactions impact blood pressure regulation.