Azza A Al-Sissi, Sherif Y El-Nagdy, Mohamed I Mourad and Mona Denewar
Objectives: The present study was carried out to analyze the genetic alterations among primary malignant salivary gland tumors and pleomorphic adenoma using RAPD to identify new genetic markers of clinical relevance to these tumors.
Methods: DNA was extracted from paraffin-embedded tissue biopsies of the studied cases. RAPD-PCR was performed using 8 different primers. The isolated genes were sequenced by the automated gene sequencer.
Results: In the current study, the identified genes were collagen type IV, alpha 4, polyprotein, large tumor suppressor (LATS) gene, cytokinin receptor at CKI2-like protein or kinesin family member 3C, isoform and tumor susceptibility gene 101(TSG 101).
Conclusion: The results of the current work explored that retroviruses may play a role in salivary gland tumors. Moreover, there are common gene markers, pathways and themes shared among the various types of salivary gland tumors. In addition, effective drug development should focus on targeting these key players upon which multiple oncogenic pathways converge.
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