药物化学

Recent Advances in Natural Product-Based NFâ??κB Inhibitors as Anticancer and Anti-Inflammatory Agents

Abstract

Arijit Nandi, Anwesha Das

An enormous number of articles hold up that the nuclear factor kappa B (NF-κB) pathway can modulate the pathophysiological conditions of cancer, inflammation, and numerous central nervous system diseases. Surprisingly, for such an important transcription factor, little progress has been made in uncovering the specific effects of the naturally occurring compounds in NF-κB pathway inhibitors. Several natural products and traditional medicines are extensively used by people worldwide in different disease conditions having unknown mechanisms. Among this undiscovered domain, a large number of compounds are isolated and showing their modulatory activity on the NF-κB pathway.