..

分子生物标志物与诊断杂志

Recent Developments in Radiation Therapy Decision Making in Early Invasive Breast Cancer

Abstract

Nazia Riaz*

Adjuvant whole-breast irradiation following breast-conserving surgery is a well-established treatment standard for early invasive breast cancer. Screening, early diagnosis, surgical technique refinement, knowledge of new and specific molecular prognostic factors, and now the standard use of more effective neo/adjuvant systemic therapies have all played a role in lowering the rates of locoregional relapses. This highlights the importance of reliably identifying women with such low-risk disease burdens in whom removing radiation from the treatment plan would not jeopardise oncological safety. This review summarises the current evidence for radiation de-intensification strategies and details ongoing prospective clinical trials investigating the omission of adjuvant whole breast irradiation in molecularly defined low-risk breast cancers, as well as related evidence supporting the potential for radiation de-escalation in triple-negative clinical subtypes.

免责声明: 此摘要通过人工智能工具翻译,尚未经过审核或验证

分享此文章

索引于

相关链接

arrow_upward arrow_upward