细胞学与组织学杂志

Short and Long Term Administration of Gold Nanorods Induces Hepatic and Renal Toxicities in Male Albino Rats

Abstract

Mahmoud A A Said*, Ahmed S Abdoon, Sayed A Aziz, Gamal Shams, Al-Sayed R Al-attar, M Ihab Fetouh and Sameh M El Nabtity

Gold nanoparticles are known by its good penetrating ability and translocation into cells. Despite their convenience, they can induce biochemical abnormalities and tissue toxicity. This study aimed to investigate the possibility of hepato-renal toxicities induced by gold nanorods (AuNRs) on liver and kidney tissues at short and long term basis. The experimental design was subdivided into short term study (AuNRs 300 μg/kg body weight i.p) and long term study (AuNRs 30 μg/kg body weight i.p), where adult male albino rats were used and allocated into two equal groups. The first group received IP injection of normal saline 0.9% and the second group received AuNRs. At the end of the experiment, five animals from each group were sacrificed and blood was collected on plain test tubes for biochemical study. Liver and kidney tissues were collected from both groups, and preserved a buffered formalin solution for histopathological examination. The high dose of gold nanorods induced a significant increase in Oxidant enzymes and liver and kidney function as well as degeneration and necrotic changes corresponding to control group. It has been concluded that short and long term intraperitoneal administration of gold nanorods adversely affected the biochemical and hepatorenal histomorphological architecture.