癌症科学与治疗

Tp53基因脯氨酸等位基因、Arg72pro多态性与脑肿瘤的显著关联及其预后价值

Abstract

???·???·??????·????????·???·??????·????·???????·??·?????·S·?????·???????·H·???????????·?????????·???·???

???? TP53 ????Arg72Pro ???????????????????????????????????? TP53 Arg72Pro ?????????????????????????????????????????????????

??????? 90 ??????????????? 130 ??????????????????????????? (PCR-RFLP) ???? TP53 Arg72Pro ????

??????? Pro ??????????? 0.47????? 0.37????????p<0.05??????? TP53?72Pro ??????24.4%???????17.7%?????? 1.9?????????p>0.05???????????/????GC???????????????????????p<0.05??????????????????????????????p>0.05??

???????????????????? TP53 Arg72Pro ???????????????????????????????