癌症科学与治疗

TGF βRI基因终止密码子调节 3D 结构的功能活性及其在 Wilms 肿瘤中的遗传易感性

Abstract

Ajit Kumar Saxena?Veena Singh?Aprajita?Aniket Kumar?Meenakshi Tiwari?Pritanjali Singh?Chandan K Singh ? Ramanuj K

??????β??1??TGF-βR1??????????????????????????????????????????????TGF-βR1???????????CNV????????DNA????????????????3D?????????????????????????????RT-PCR????????????DNA???Sanger?????CNV??????????????WT???TGF-βR1????????18.18??????Tm ??????? 90.70 ?? 91.0?????????p=0.24??95% ? CI ? 2.09-7.09 ???????????? SD=0.37?95% ? CI ? 0.337-0.906????????????????? TGA→TCA ? TGA→CCC????????????????????“?????”????/??????????????????? 3-D ??????????????????????????????????