微生物学和病理学杂志

Surviving the Battle: The Elusive Strategies of Immune Evasion

Abstract

B. Brett Finlay

The immune system is a formidable defense mechanism that protects organisms from invading pathogens. However, many pathogens have evolved sophisticated strategies to evade detection and neutralization by the host immune system, enabling their survival and propagation within the host. This review delves into the fascinating world of immune evasion strategies employed by various pathogens, including viruses, bacteria, and parasites. We explore the diverse mechanisms utilized by these pathogens to avoid recognition by the immune system, such as antigenic variation, immune mimicry, and interference with immune signaling pathways. Additionally, we highlight the role of host-pathogen co-evolution in shaping these evasion tactics. Understanding the elusive strategies of immune evasion is crucial for developing novel therapeutic interventions and vaccines to combat infectious diseases effectively.