癌症科学与治疗

环取代四氢异喹啉(THIQ)的合成及作为抗乳腺癌药物的生物学评价

Abstract

Suresh VK Eyunni?Madhavi Gangapuram?Bereket Mochona?Nelly Mateeva???·K·??

????????????????????? 50 ??????????????????????????????????????????????????? ????????????????????????????????????????????? (THIQ) ???????????????/?????????????????????????????? ??????????????? (THIQ) ???? ?? CellTiter-Glo ?????????????????????????????? ER (+) MCF-7 ??????ER (-) MDA-MB-231 ????????????????????????????????????????? 2b?2i ? 3g???? MCF-7 ?????????? (IC ₅₀ =0.2μg/mL?0.08μg/mL?0.61μg/mL?0.09μg/mL?0.25μg/mL?0.11μg/mL ) (IC 50 ₌ 3.99 μg/mL?7.87 μg/mL)???????????? ER-α?PDB?3ERT??ER-β?PDB?1QKN?? α-β?????????? (1JFF) ??????????????????????????? ?????????