Zohra Benfodda, Vanessa Fritz, Corinne Henriquet, Caterina Fattorusso, Gerardo Cebrián-Torrejón, Marco Persico, Antonio Di Dato, Marialuisa Menna, Hubert Blancou and Lluis Fajas
A series of 1-acyl-4-sulfonylpiperazine derivatives has been prepared. The antiproliferative effect of these compounds was evaluated in vitro against human prostate cancer cell line C4-2, several among them exhibited interesting growth inhibitory against this particular cell line. Finally, a molecular modeling study was employed to analyze the structure/activity relationships (SAR) of these novel compounds..
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