药物化学

Synthesis of Multi-Target Benzene-Sulphonamide Derivatives for the Treatment of Trypanosomiasis

Abstract

David I Ugwu, Florence U Eze, Blessing C Ogboo, Victor N Okoro, Mirabel C Ugwu, Sunday N Okafor, Jude I Ayogu and Solomon I Attah

Some derivatives of benzene-sulphonamides were synthesized via condensation reaction. Pharmacokinetic parameters were evaluated to assess the oral bioavailability, permeability and transport properties of the compounds. Molecular docking studies were performed on farnesyl diphosphate synthase, pteridine reductase, ornithine decarboxylase and rhodesain to assess the potential of the reported compounds in treating human African trypanosomiasis. All the compounds showed good binding to the target proteins assayed.